Collagen

by mhcrawford

1. Describe the primary structure of collagen. What are the major amino acid components?
 1s of C(3Helix)= 2A(P/HP)+AG(rep)
Translation: The primary structure of collage(the triple helix) is 2 Aminos(either proline or hydroxypoline) and the amino glycine, and then it repeats.
2. What role does vitamin C play in collagen formation? What happens when a person does not get enough vitamin C in his or her diet?
H+VC=O+Construction
Hydroxyproline and vitamin C make construction happen, vitamin C ultimately providing in the oxygen.
H-VC=S
Hydroxyproline minus vitamin C results in signs of scurvy, very damaging.

3. Describe the quaternary structure of collagen (the way in which the polypeptide chains are arranged).
Qs=3lhH~rhc
The quaternary structure is made of 3 left hand helices twisted in right hand coils.

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1. What is the main symptom of osteogenesis imperfecta?  What are some other symptoms that people with OI may have?
The main symptom of osteogenesis imperfecta is fragile bones that break easily. Some other symptoms are muscle weakness,  fatigue, and short stature. Bone deformations also come along.
2. Type I osteogenesis imperfecta causes fewer problems than the other forms. How does the collagen structure in Type I OI differ from that of the other types?
The collagen structure in type I osteogenesis imperfecta is completely normal, thus the fewer problems in it than in other forms.
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1. Describe the role of collagen in bones. Why do collagen problems lead to bone problems?
Collagen, from what I understand, is like a supportive, strong, elastic frame.  Without it, bone is a cinder block. It can be broken easily with a small amount of pressure due to the brittle nature. If there are collagen problems, it may break much easier. Imagine if a vertebrae broke. It would collapse, add pressure, and break the next one, and the next. Major problem. Like a fighter, bones need strength, and resilience.
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